Rabbit anti-Human CD85j Polyclonal Antibody

Uniprot Id

Q8NHL6

Target Species

Human

Target Name

LILRB1

Target Full Name

Leukocyte immunoglobulin-like receptor subfamily B member 1

Target Function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Secreted.

Target Tissue Specificity

Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level). Expressed in decidual macrophages (at protein level). Expressed in decidual NK cells (at protein level).

Target Synonyms

CD85; CD85 antigen; CD85 antigen like family member J; CD85 antigen-like family member J; CD85j; CD85j antigen; Ig like transcript 2; ILT 2; ILT-2; ILT2; immunoglobulin like transcript 2; Immunoglobulin-like transcript 2; leukocyte Ig like receptor 1; Leukocyte immunoglobulin like receptor 1; leukocyte immunoglobulin like receptor subfamily B member 1; Leukocyte immunoglobulin like receptor subfamily B member 1 precursor; leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin like receptor, subfamily B, member 1; Leukocyte immunoglobulin-like receptor 1; Leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LILRB1; LIR 1; LIR-1; LIR1; LIRB1_HUMAN; MIR 7; MIR-7; MIR7; Monocyte/macrophage immunoglobulin like receptor 7; Monocyte/macrophage immunoglobulin-like receptor 7; PIR B; PIRB

Target Background

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.