Rabbit anti-Human PRELID1 Polyclonal Antibody

Uniprot Id

Q9Y255

Target Species

Human

Target Name

PRELID1

Target Full Name

PRELI domain-containing protein 1, mitochondrial

Target Function

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.

Target Subcellular Location

Mitochondrion. Mitochondrion intermembrane space.

Target Tissue Specificity

Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.

Target Research Area

Metabolism

Target Synonyms

25 kDa protein of relevant evolutionary and lymphoid interest; CGI 106; MGC87972; mitochondrial; PRELI; PRELI domain containing 1; PRELI domain containing protein 1; PRELI domain containing protein 1 mitochondrial; PRELI domain-containing protein 1; PRELID 1; PRELID1; PRLD1_HUMAN; Protein of relevant evolutionary and lymphoid interest; PX 19; PX19; Px19 like protein; Px19, chicken, homolog of; Px19-like protein; SBBI12

Target Background

This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified.