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The antibody against TAT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TAT (NP_000344.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against TAT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TAT (NP_000344.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-08607A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TAT |
| Target Synonyms | TAT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, A673, BT-474, HepG2, Mouse liver, Raji, Rat liver | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TAT (NP_000344.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P17735 | Immunogen Sequence |
Uniprot Id
P17735
Target Species
Human
Target Name
TAT
Target Full Name
Tyrosine aminotransferase
Target Function
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Target Involvement
Tyrosinemia 2 (TYRSN2)
Target Protein Families
Class-I pyridoxal-phosphate-dependent aminotransferase family
Target Synonyms
ATTY_HUMAN; L-tyrosine:2-oxoglutarate aminotransferase; TAT; Tyrosine aminotransferase; Tyrosine aminotransferase; cytosolic
Target Background
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked.
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