Rabbit anti-Human IER3 Polyclonal Antibody

The antibody against IER3 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 50-150 of human IER3 (NP_003888.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-08961A

Number

Cat.No	ADA-08961A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	IER3
Target Synonyms	DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L; IER3	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	MCF7, Mouse testis, SW620	Application	ELISA, WB, IHC-P

Cat.No

ADA-08961A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

IER3

Target Synonyms

DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L; IER3

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

MCF7, Mouse testis, SW620

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IER3 (NP_003888.2).	Target Species	Human
Immunogen Sequence	GRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQ	Uniprot ID	P46695

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IER3 (NP_003888.2).

Target Species

Human

Immunogen Sequence

GRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQ

Uniprot ID

P46695

Background Information

Uniprot Id

P46695
Target Species

Human
Target Name

IER3
Target Full Name

Radiation-inducible immediate-early gene IEX-1
Target Function

May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Target Subcellular Location

Membrane; Single-pass type II membrane protein.
Target Protein Families

IER3 family
Target Synonyms

IER3; DIF2; IEX1; PRG1; Radiation-inducible immediate-early gene IEX-1; Differentiation-dependent gene 2 protein; Protein DIF-2; Immediate early protein GLY96; Immediate early response 3 protein; PACAP-responsive gene 1 protein; Protein PRG1
Target Background

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.

Rabbit anti-Human IER3 Polyclonal Antibody

Specifications

Immunogen Information

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