Rabbit anti-Human ESRRB Polyclonal Antibody

Uniprot Id

O95718

Target Species

Human

Target Name

ESRRB

Target Full Name

Steroid hormone receptor ERR2

Target Function

Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation.; Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.

Target Involvement

Deafness, autosomal recessive, 35 (DFNB35)

Target Subcellular Location

Nucleus. Cytoplasm. Chromosome.

Target Protein Families

Nuclear hormone receptor family, NR3 subfamily

Target Synonyms

Err 2; ERR b; ERR B2; ERR beta 2; ERR beta; ERR beta-2; ERR-beta; Err2; ERR2_HUMAN; ERRB 2; ERRb; ERRB2; ERRbeta 2; ERRbeta; ESR L2; ESRL 2; ESRL2; Esrrb; Estrogen receptor like 2; Estrogen receptor related 2; Estrogen receptor-like 2; Estrogen-related receptor beta; Estrrb; Nr3b2; Nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; Orphan nuclear receptor; Steroid hormone receptor ERR 2; Steroid hormone receptor ERR2

Target Background

This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.