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The antibody against NUDT15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against NUDT15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-09061A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NUDT15 |
| Target Synonyms | MTH2; NUDT15D; NUDT15 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HT-29, Raji | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human NUDT15 (NP_060753.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL | Uniprot ID | Q9NV35 |
Uniprot Id
Q9NV35
Target Species
Human
Target Name
NUDT15
Target Full Name
Nucleotide triphosphate diphosphatase NUDT15
Target Function
May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.
Target Protein Families
Nudix hydrolase family
Target Synonyms
8-dihydro-8-oxoguanine triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; EC 3.1.6.-; FLJ10956; MGC104352; MTH2; MutT homolog 2; Nucleoside diphosphate-linked moiety X motif 15; NUD15_HUMAN; Nudix (nucleoside diphosphate linked moiety X)-type motif ; Nudix motif 15; NUDT15; OTTHUMP00000018389; Probable 7; Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; RP11-90M2.1
Target Background
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
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