Rabbit anti-Human CLSPN Polyclonal Antibody

The antibody against CLSPN was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 650-750 of human CLSPN (NP_001177410.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09277A

Number

Cat.No	ADA-09277A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CLSPN
Target Synonyms	CLSPN; claspin	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HepG2, Jurkat	Application	ELISA, WB

Cat.No

ADA-09277A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CLSPN

Target Synonyms

CLSPN; claspin

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, Jurkat

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CLSPN (NP_001177410.1).	Target Species	Human
Immunogen Sequence	SVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLF	Uniprot ID	Q9HAW4

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CLSPN (NP_001177410.1).

Target Species

Human

Immunogen Sequence

SVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLF

Uniprot ID

Q9HAW4

Background Information

Uniprot Id

Q9HAW4
Target Species

Human
Target Name

CLSPN
Target Full Name

Claspin
Target Function

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Target Subcellular Location

Nucleus.
Target Protein Families

Claspin family
Target Synonyms

Claspin; claspin homolog (Xenopus laevis); Claspin homolog; CLSPN; CLSPN protein; CLSPN_HUMAN; hClaspin; Hu Claspin
Target Background

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human CLSPN Polyclonal Antibody

Specifications

Immunogen Information

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