Rabbit anti-Human YWHAZ Polyclonal Antibody

Uniprot Id

P63104

Target Species

Human

Target Name

YWHAZ

Target Full Name

14-3-3 protein zeta/delta

Target Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity.

Target Subcellular Location

Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.

Target Protein Families

14-3-3 family

Target Research Area

Cell Biology

Target Synonyms

14 3 3 delta; 14 3 3 protein zeta/delta; 14 3 3 protein/cytosolic phospholipase A2; 14 3 3 zeta; 14-3-3 protein zeta/delta; 1433Z_HUMAN; Epididymis luminal protein 4; Epididymis secretory protein Li 3; HEL S 3; HEL4; KCIP-1; KCIP1; MGC111427; MGC126532; MGC138156; Phospholipase A2; Protein kinase C inhibitor protein 1; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; delta polypeptide; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; zeta; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; zeta polypeptide; Tyrosine 3/tryptophan 5 monooxygenase activation protein; zeta polypeptide; YWHAD; YWHAZ

Target Background

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.