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The antibody against WBSCR22 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human WBSCR22 (NP_059998.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against WBSCR22 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human WBSCR22 (NP_059998.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09344A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WBSCR22 |
| Target Synonyms | WBMT; MERM1; PP3381; HUSSY-3; WBSCR22; HASJ4442 | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, NCI-H460 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human WBSCR22 (NP_059998.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43709 | Immunogen Sequence |
Uniprot Id
O43709
Target Species
Human
Target Name
BUD23
Target Full Name
18S rRNA (guanine-N(7))-methyltransferase
Target Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro
Target Involvement
BUD23 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BUD23 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Target Subcellular Location
Nucleus. Nucleus, nucleoplasm. Cytoplasm, perinuclear region. Cytoplasm.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, BUD23/WBSCR22 family
Target Tissue Specificity
Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level
Target Synonyms
HASJ4442 ; HUSSY 3; HUSSY3; PP3381 ; Uncharacterized methyltransferase WBSCR22; WBMT ; WBS22_HUMAN; WBSCR22; Williams Beuren candidate region putative methyltransferase; Williams Beuren syndrome chromosome region 22 protein; Williams-Beuren syndrome chromosomal region 22 protein
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