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Rabbit anti-Human MPI Polyclonal Antibody

The antibody against MPI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human MPI (NP_002426.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09345A

The antibody against MPI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human MPI (NP_002426.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-09345A ClonalityPolyclonal
Host SpeciesRabbitTarget NameMPI
Target SynonymsPMI; PMI1; CDG1B; MPIFormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesHeLa, Mouse heart, HepG2, Jurkat, SW620ApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 1-423 of human MPI (NP_002426.1).Target SpeciesHuman
Uniprot IDP34949Immunogen Sequence
Background Information
  • Uniprot Id

    P34949

  • Target Species

    Human

  • Target Name

    MPI

  • Target Full Name

    Mannose-6-phosphate isomerase

  • Target Function

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

  • Target Involvement

    Congenital disorder of glycosylation 1B (CDG1B)

  • Target Subcellular Location

    Cytoplasm.

  • Target Protein Families

    Mannose-6-phosphate isomerase type 1 family

  • Target Tissue Specificity

    Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.

  • Target Research Area

    Signal Transduction

  • Target Synonyms

    MI1; CDG1B; FLJ39201; Mannose 6 phosphate isomerase; Mannose-6-phosphate isomerase; MANNOSEPHOSPHATE ISOMERASE; MGC94106; MPI; MPI_HUMAN; Phosphohexomutase; phosphomannose isomerase 1; Phosphomannose isomerase; PMI

  • Target Background

    Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants.

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