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The antibody against SRP54 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 196-455 of human SRP54 (NP_001139754.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SRP54 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 196-455 of human SRP54 (NP_001139754.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09768A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SRP54 |
| Target Synonyms | SCN8; SRP54 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, A-549, Mouse brain, Mouse liver, Mouse lung | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 196-455 of human SRP54 (NP_001139754.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P61011 | Immunogen Sequence |
Uniprot Id
P61011
Target Species
Human
Target Name
SRP54
Target Full Name
Signal recognition particle subunit SRP54
Target Function
Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
Target Subcellular Location
Nucleus speckle. Cytoplasm. Endoplasmic reticulum.
Target Protein Families
GTP-binding SRP family, SRP54 subfamily
Target Research Area
Signal Transduction
Target Synonyms
Signal recognition particle 54 kDa protein; Signal recognition particle 54kDa; SRP 54; SRP54; SRP54_HUMAN
Target Background
Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8.
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