Rabbit anti-Human IRF2 Polyclonal Antibody

The antibody against IRF2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human IRF2 (NP_002190.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.

ADA-09868A

Number

Cat.No	ADA-09868A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	IRF2
Target Synonyms	IRF-2; IRF2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Jurkat, Mouse lung	Application	ELISA, WB, IF/ICC, IHC-P

Cat.No

ADA-09868A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

IRF2

Target Synonyms

IRF-2; IRF2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Jurkat, Mouse lung

Application

ELISA, WB, IF/ICC, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human IRF2 (NP_002190.2).	Target Species	Human
Uniprot ID	P14316	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human IRF2 (NP_002190.2).

Target Species

Human

Uniprot ID

P14316

Immunogen Sequence

Background Information

Uniprot Id

P14316
Target Species

Human
Target Name

IRF2
Target Full Name

Interferon regulatory factor 2
Target Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Target Subcellular Location

Nucleus.
Target Protein Families

IRF family
Target Tissue Specificity

Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Target Synonyms

DKFZp686F0244; Interferon regulatory factor 2; IRF 2; IRF-2; IRF2; IRF2_HUMAN
Target Background

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.

Rabbit anti-Human IRF2 Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human IRF2 Polyclonal Antibody Now

Related Products