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The antibody against CHAT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 331-630 of human CHAT (NP_065574.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against CHAT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 331-630 of human CHAT (NP_065574.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of paraffin-embedded human liver cancer using CHAT antibody at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-10345A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHAT |
| Target Synonyms | CMS6; CMS1A; CMS1A2; CHOACTASE; CHAT | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 331-630 of human CHAT (NP_065574.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P28329 | Immunogen Sequence |
Uniprot Id
P28329
Target Species
Human
Target Name
CHAT
Target Full Name
Choline O-acetyltransferase
Target Function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Target Involvement
Myasthenic syndrome, congenital, 6, presynaptic (CMS6)
Target Protein Families
Carnitine/choline acetyltransferase family
Target Research Area
Neuroscience
Target Synonyms
Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O acetyltransferase; Choline O-acetyltransferase; CLAT_HUMAN; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584
Target Background
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
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