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The antibody against MRPL40 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 45-206 of human MRPL40 (NP_003767.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MRPL40 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 45-206 of human MRPL40 (NP_003767.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10553A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MRPL40 |
| Target Synonyms | URIM; L40mt; NLVCF; MRPL22; MRP-L22; MRP-L40; MRPL40 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, BxPC-3, U2OS | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 45-206 of human MRPL40 (NP_003767.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MRSEPLRKKKKVDPKKDQEAKERLKRKIRKLEKATQELIPIEDFITPLKFLDKARERPQVELTFEETERRALLLKKWSLYKQQERKMERDTIRAMLEAQQEALEELQLESPKLHAEAIKRDPNLFPFEKEGPHYTPPIPNYQPPEGRYNDITKVYTQVEFKR | Uniprot ID | Q9NQ50 |
Uniprot Id
Q9NQ50
Target Species
Human
Target Name
MRPL40
Target Full Name
Large ribosomal subunit protein mL40
Target Subcellular Location
Mitochondrion.
Target Protein Families
Mitochondrion-specific ribosomal protein mL40 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
MRPL40; NLVCF; URIM; 39S ribosomal protein L40; mitochondrial; L40mt; MRP-L40; Mitochondrial large ribosomal subunit protein mL40; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; Up-regulated in metastasis
Target Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.
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