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The antibody against Desmoplakin was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human Desmoplakin (NP_004406.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against Desmoplakin was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human Desmoplakin (NP_004406.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-11024A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Desmoplakin |
| Target Synonyms | DP; DCWHKTA; Desmoplakin | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, A-431 | Application | ELISA, WB, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Desmoplakin (NP_004406.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MSCNGGSHPRINTLGRMIRA | Uniprot ID | P15924 |
Uniprot Id
P15924
Target Species
Human
Target Name
DSP
Target Full Name
Desmoplakin
Target Function
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Target Involvement
Keratoderma, palmoplantar, striate 2 (SPPK2); Cardiomyopathy, dilated, with woolly hair and keratoderma (DCWHK); Arrhythmogenic right ventricular dysplasia, familial, 8 (ARVD8); Skin fragility-woolly hair syndrome (SFWHS); Epidermolysis bullosa, lethal acantholytic (EBLA); Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis (DCWHKTA)
Target Subcellular Location
Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane.
Target Protein Families
Plakin or cytolinker family
Target Tissue Specificity
Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.
Target Research Area
Signal Transduction
Target Synonyms
250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; Desmoplakin (DPI DPII); Desmoplakin; Desmoplakin I ; Desmoplakin II; DESP_HUMAN; DP; DP I; DP II; DPI; DPII; DSP; KPPS2; PPKS 2; PPKS2
Target Background
This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.
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