Rabbit anti-Human FLNC Polyclonal Antibody

The antibody against FLNC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 2160-2340 of human FLNC (NP_001449.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-11153A

Number

Cat.No	ADA-11153A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Flnc
Target Synonyms	ABPA; ABPL; FLN2; MFM5; MPD4; RCM5; CMH26; ABP-280; ABP280A; FLNC	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	NIH/3T3, A-549, LO2	Application	ELISA, WB, IF/ICC

Cat.No

ADA-11153A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Flnc

Target Synonyms

ABPA; ABPL; FLN2; MFM5; MPD4; RCM5; CMH26; ABP-280; ABP280A; FLNC

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

NIH/3T3, A-549, LO2

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 2160-2340 of human FLNC (NP_001449.3).	Target Species	Human
Immunogen Sequence	IPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTR	Uniprot ID	Q14315

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 2160-2340 of human FLNC (NP_001449.3).

Target Species

Human

Immunogen Sequence

IPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTR

Uniprot ID

Q14315

Background Information

Uniprot Id

Q14315
Target Species

Human
Target Name

FLNC
Target Full Name

Filamin-C
Target Function

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Target Involvement

Myopathy, myofibrillar, 5 (MFM5); Myopathy, distal, 4 (MPD4); Cardiomyopathy, familial hypertrophic 26 (CMH26); Cardiomyopathy, familial restrictive 5 (RCM5)
Target Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
Target Protein Families

Filamin family
Target Tissue Specificity

Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney.
Target Synonyms

FLNC; ABPL; FLN2Filamin-C; FLN-C; FLNc; ABP-280-like protein; ABP-L; Actin-binding-like protein; Filamin-2; Gamma-filamin

Rabbit anti-Human FLNC Polyclonal Antibody

Specifications

Immunogen Information

Inquire Rabbit anti-Human FLNC Polyclonal Antibody Now

Related Products