Rabbit anti-Human AHCY Polyclonal Antibody

The antibody against AHCY was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 253-432 of human AHCY (NP_000678.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-11212A

Number

Cat.No	ADA-11212A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AHCY
Target Synonyms	SAHH; adoHcyase; AHCY	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse liver, Mouse pancreas, Rat liver	Application	ELISA, WB, IF/ICC

Cat.No

ADA-11212A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AHCY

Target Synonyms

SAHH; adoHcyase; AHCY

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse liver, Mouse pancreas, Rat liver

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 253-432 of human AHCY (NP_000678.1).	Target Species	Human
Immunogen Sequence	AMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY	Uniprot ID	P23526

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 253-432 of human AHCY (NP_000678.1).

Target Species

Human

Immunogen Sequence

AMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY

Uniprot ID

P23526

Background Information

Uniprot Id

P23526
Target Species

Human
Target Name

AHCY
Target Full Name

Adenosylhomocysteinase
Target Function

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Target Involvement

Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Target Subcellular Location

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target Protein Families

Adenosylhomocysteinase family
Target Research Area

Metabolism
Target Synonyms

Adenosylhomocysteinase; AdoHcyase; ahcY; S adenosyl L homocysteine hydrolase; S adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase; SAHH; SAHH_HUMAN
Target Background

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human AHCY Polyclonal Antibody

Specifications

Immunogen Information

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