Name: ACO1 Recombinant Monoclonal Antibody
SKU: ADC-56690A
Availability: InStock

ACO1 Recombinant Monoclonal Antibody

The recombinant antibody against ACO1 was produced using a synthesized peptide derived from human ACO1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IF, FC.

ADC-56690A

$350.00

Number

Cat.No

ADC-56690A

Clonality

Monoclonal

Target Name

ACO1

Target Synonyms

ACO1, Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1), IREB1

Form

Liquid

Species Reactivity

Human

Isotype

Rabbit IgG

Storage Buffer

PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline

Purification Method

Affinity-chromatography purified

Conjugate

Non-conjugated

Application

ELISA, IF, WB, FC

Storage

Upon receipt

Immunogen Description

A synthesized peptide derived from human ACO1

Target Species

Human

Immunogen Sequence

Complete sequences for the immunogen, target protein, and peptides are available upon request.

Uniprot ID

P21399

Background Information

Uniprot Id

P21399
Target Species

Human
Target Name

ACO1
Target Full Name

Cytoplasmic aconitate hydratase
Target Function

Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA.; Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

Aconitase/IPM isomerase family
Target Synonyms

ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1; OTTHUMP00000045233
Target Background

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants

ACO1 Recombinant Monoclonal Antibody

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