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The recombinant antibody against AXIN2 was produced using a synthesized peptide derived from human AXIN2 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA.
The recombinant antibody against AXIN2 was produced using a synthesized peptide derived from human AXIN2 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA.
$350.00
| Cat.No | ADC-56223A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | AXIN2 | Form | Liquid |
| Species Reactivity | Human | Isotype | Rabbit IgG |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline | Purification Method | Affinity-chromatography purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human AXIN2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y2T1 |
Uniprot Id
Q9Y2T1
Target Species
Human
Target Name
AXIN2
Target Full Name
Axin-2
Target Function
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Target Involvement
Colorectal cancer (CRC); Oligodontia-colorectal cancer syndrome (ODCRCS)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in brain and lymphoblast.
Target Research Area
Cancer
Target Synonyms
Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; AXIN2_HUMAN; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Target Background
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
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