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The antibody against PIGR was raised in rabbit using the Recombinant Bovine Polymeric immunoglobulin receptor protein (399-599AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against PIGR was raised in rabbit using the Recombinant Bovine Polymeric immunoglobulin receptor protein (399-599AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-46130A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PIGR |
| Target Synonyms | PIGR antibody; Polymeric immunoglobulin receptor antibody; PIgR antibody; Poly-Ig receptor) [Cleaved into: Secretory component] antibody | Form | Liquid |
| Species Reactivity | Bovine | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Bovine Polymeric immunoglobulin receptor protein (399-599AA) | Target Species | Bos taurus (Bovine) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P81265 |
Uniprot Id
P81265
Target Species
Bovine
Target Name
PIGR
Target Function
Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.; Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
Target Subcellular Location
[Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein.; [Secretory component]: Secreted.
Target Tissue Specificity
Found in mammary gland, jejunum, lung, kidney and small intestine.
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