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The recombinant antibody against CEACAM5 was produced using the Recombinant Human CEACAM5 protein as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IF, FC.
The recombinant antibody against CEACAM5 was produced using the Recombinant Human CEACAM5 protein as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IF, FC.
$350.00
Immunofluorescence staining of Hela cell with CEACAM5 Recombinant Monoclonal Antibody at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).
Immunofluorescence staining of MCF7 cell with CEACAM5 Recombinant Monoclonal Antibody at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).2
| Cat.No | ADC-56425A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | CEACAM5 | Form | Liquid |
| Species Reactivity | Human | Isotype | Rabbit IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Affinity-chromatography purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, FC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human CEACAM5 protein | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P06731 |
Uniprot Id
P06731
Target Species
Human
Target Name
CEACAM5
Target Full Name
Cell adhesion molecule CEACAM5
Target Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface.
Target Protein Families
Immunoglobulin superfamily, CEA family
Target Tissue Specificity
Expressed in columnar epithelial and goblet cells of the colon (at protein level). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Target Research Area
Cancer
Target Synonyms
CEA; CD66e; CEACAM5
Target Background
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
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