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The recombinant antibody against CHAT was produced using a synthesized peptide derived from Human CHAT as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IHC, IF, FC.
The recombinant antibody against CHAT was produced using a synthesized peptide derived from Human CHAT as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IHC, IF, FC.
$350.00
Western Blot | Positive WB detected in: Mouse Brain tissue lysate | All lanes: CHAT antibody at 1:500 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 70 kDa | Observed band size: 70 kDa
| Cat.No | ADC-56554A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | CHAT | Target Synonyms | CHAT, Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB, FC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from Human CHAT | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P28329 |
Uniprot Id
P28329
Target Species
Human
Target Name
CHAT
Target Full Name
Choline O-acetyltransferase
Target Function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Target Involvement
Myasthenic syndrome, congenital, 6, presynaptic (CMS6)
Target Protein Families
Carnitine/choline acetyltransferase family
Target Research Area
Neuroscience
Target Synonyms
Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; Choline O acetyltransferase; Choline O-acetyltransferase; CLAT_HUMAN; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584
Target Background
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.
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