CLDN18 Recombinant Monoclonal Antibody

Uniprot Id

P56856

Target Species

Human

Target Name

CLDN18

Target Full Name

Claudin-18

Target Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Target Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Claudin family

Target Tissue Specificity

Isoform A1: Expression is restricted to the lung. Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine c

Target Research Area

Signal Transduction

Target Synonyms

CLDN18; UNQ778/PRO1572; Claudin-18

Target Background

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.