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The antibody against NPC2 was raised in rabbit using the Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against NPC2 was raised in rabbit using the Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-45653A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NPC2 |
| Target Synonyms | NPC2 antibody; NPC intracellular cholesterol transporter 2 antibody; Epididymal secretory protein E1 antibody; cE1 antibody; Niemann Pick type C2 protein homolog antibody | Form | Liquid |
| Species Reactivity | Dog | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA) | Target Species | Dog |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q28895 |
Uniprot Id
Q28895
Target Species
Dog
Target Name
NPC2
Target Function
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Target Subcellular Location
Secreted. Endoplasmic reticulum. Lysosome.
Target Protein Families
NPC2 family
Target Tissue Specificity
Epididymis. High levels are found in the caput and corpus regions. Weaker levels in the distal cauda and in the efferent ducts.
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