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The antibody against LMP2 was raised in rabbit using the Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against LMP2 was raised in rabbit using the Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-10610A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LMP2 |
| Target Synonyms | LMP2 antibody; Latent membrane protein 2 antibody; Terminal protein antibody | Form | Liquid |
| Species Reactivity | Epstein-Barr virus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA) | Target Species | Epstein-Barr virus |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P13285 |
Uniprot Id
P13285
Target Species
Epstein-Barr virus
Target Name
LMP2
Target Function
Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.; Isoform LMP2B may be a negative regulator of isoform LMP2A.
Target Subcellular Location
[Isoform LMP2A]: Host cell membrane; Multi-pass membrane protein.; [Isoform LMP2B]: Host endomembrane system; Multi-pass membrane protein. Host cytoplasm, host perinuclear region.
Target Protein Families
Herpesviridae LMP-2 family
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