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The recombinant antibody against FASN was produced using a synthesized peptide derived from human FASN as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IF, FC.
The recombinant antibody against FASN was produced using a synthesized peptide derived from human FASN as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IF, FC.
$350.00
| Cat.No | ADC-57013A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | FASN | Target Synonyms | [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39), 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100), 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41), Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39), FAS, FASN, Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38), Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, FC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human FASN | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49327 |
Uniprot Id
P49327
Target Species
Human
Target Name
FASN
Target Full Name
Fatty acid synthase
Target Function
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
Target Subcellular Location
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target Tissue Specificity
Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.
Target Synonyms
[Acyl-carrier-protein] S acetyltransferase; [Acyl-carrier-protein] S malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; FAS; FAS_HUMAN; FASN; Fatty acid synthase; MGC14367; MGC15706; OA 519; Oleoyl-[acyl-carrier-protein] hydrolase; SDR27X1; Short chain dehydrogenase/reductase family 27X member 1
Target Background
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
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