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The antibody against P was raised in rabbit using the Recombinant Hepatitis B virus genotype A2 subtype adw2 Protein P protein (349-692AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against P was raised in rabbit using the Recombinant Hepatitis B virus genotype A2 subtype adw2 Protein P protein (349-692AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-20667A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | P |
| Target Synonyms | PProtein P [Includes: DNA-directed DNA polymerase antibody; EC 2.7.7.7); RNA-directed DNA polymerase antibody; EC 2.7.7.49); Ribonuclease H antibody; EC 3.1.26.4)] antibody | Form | Liquid |
| Species Reactivity | Hepatitis B virus genotype A2 subtype adw2 | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Hepatitis B virus genotype A2 subtype adw2 Protein P protein (349-692AA) | Target Species | Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P17100 |
Uniprot Id
P17100
Target Species
Hepatitis B virus genotype A2 subtype adw2
Target Name
P
Target Function
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
Target Protein Families
Hepadnaviridae P protein family
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