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The antibody against 4-1BB/CD137 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human 4-1BB/CD137 (NP_001552.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against 4-1BB/CD137 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human 4-1BB/CD137 (NP_001552.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-04429A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | 4-1BB/CD137 |
| Target Synonyms | ILA; 4-1BB; CD137; CDw137; IMD109; 4-1BB/CD137 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen, Rat spleen | Application | ELISA, WB, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human 4-1BB/CD137 (NP_001552.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | SMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQIISFFLALTSTALL | Uniprot ID | Q07011 |
Uniprot Id
Q07011
Target Species
Human
Target Name
TNFRSF9
Target Full Name
Tumor necrosis factor receptor superfamily member 9
Target Function
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed on the surface of activated T-cells.
Target Synonyms
ILA; 4-1BB; CD137; CDw137; IMD109; 4-1BB/CD137
Target Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
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