Rabbit anti-Human 5T4 Monoclonal Antibody

The antibody against 5T4 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 321-420 of human 5T4 (Q13641) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-14362A

Number

Cat.No	ADA-14362A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	5T4
Target Synonyms	5T4; M6P1; 5T4AG; WAIF1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A549, MCF7	Application	ELISA, WB

Cat.No

ADA-14362A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

5T4

Target Synonyms

5T4; M6P1; 5T4AG; WAIF1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A549, MCF7

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 321-420 of human 5T4 (Q13641).	Target Species	Human
Immunogen Sequence	LTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV	Uniprot ID	Q13641

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 321-420 of human 5T4 (Q13641).

Target Species

Human

Immunogen Sequence

LTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

Uniprot ID

Q13641

Background Information

Uniprot Id

Q13641
Target Species

Human
Target Name

TPBG
Target Full Name

Trophoblast glycoprotein
Target Function

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity

Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Target Research Area

Cancer
Target Synonyms

5T4; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4AG; AW495680; M6P1; TPBG; TPBG_HUMAN; Trophoblast glycoprotein
Target Background

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.

Rabbit anti-Human 5T4 Monoclonal Antibody

Specifications

Immunogen Information

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