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The antibody against 5T4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human 5T4 (NP_006661.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against 5T4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human 5T4 (NP_006661.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05452A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | 5T4 |
| Target Synonyms | 5T4; M6P1; 5T4AG; WAIF1 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Rat brain, Rat heart, Mouse brain, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 32-350 of human 5T4 (NP_006661.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13641 | Immunogen Sequence |
Uniprot Id
Q13641
Target Species
Human
Target Name
TPBG
Target Full Name
Trophoblast glycoprotein
Target Function
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Target Research Area
Cancer
Target Synonyms
5T4; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; 5T4AG; AW495680; M6P1; TPBG; TPBG_HUMAN; Trophoblast glycoprotein
Target Background
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
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