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The antibody against AANAT was raised in rabbit using the Recombinant Human Serotonin N-acetyltransferase protein (1-207AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against AANAT was raised in rabbit using the Recombinant Human Serotonin N-acetyltransferase protein (1-207AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-05704A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AANAT |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Serotonin N-acetyltransferase protein (1-207AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q16613 |
Uniprot Id
Q16613
Target Species
Human
Target Name
AANAT
Target Full Name
Serotonin N-acetyltransferase
Target Function
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Acetyltransferase family, AANAT subfamily
Target Tissue Specificity
Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
Target Research Area
Neuroscience
Target Synonyms
AA-NAT; Aanat; Aralkylamine N-acetyltransferase; Arylalkylamine N acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT; SNAT_HUMAN
Target Background
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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