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The antibody against AARS2 was raised in rabbit using the Recombinant Human Alanine--tRNA ligase, mitochondrial protein (841-985AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against AARS2 was raised in rabbit using the Recombinant Human Alanine–tRNA ligase, mitochondrial protein (841-985AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human liver cancer using AARS2 Antibody at dilution of 1:100
| Cat.No | ADC-40372A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AARS2 |
| Target Synonyms | AARS2 antibody; AARSL antibody; KIAA1270 antibody; Alanine--tRNA ligase antibody; mitochondrial antibody; EC 6.1.1.7 antibody; Alanyl-tRNA synthetase antibody; AlaRS antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Alanine--tRNA ligase, mitochondrial protein (841-985AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5JTZ9 |
Uniprot Id
Q5JTZ9
Target Species
Human
Target Name
AARS2
Target Full Name
Alanine--tRNA ligase, mitochondrial
Target Function
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Target Involvement
Combined oxidative phosphorylation deficiency 8 (COXPD8); Leukoencephalopathy, progressive, with ovarian failure (LKENP)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Class-II aminoacyl-tRNA synthetase family
Target Synonyms
AARS2; AARSL; KIAA1270; Alanine--tRNA ligase; mitochondrial; EC 6.1.1.7; Alanyl-tRNA synthetase; AlaRS
Target Background
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
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