Rabbit anti-Human ABCA2 Polyclonal Antibody

Uniprot Id

Q9BZC7

Target Species

Human

Target Name

ABCA2

Target Full Name

ATP-binding cassette sub-family A member 2

Target Function

Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.

Target Subcellular Location

Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Target Protein Families

ABC transporter superfamily, ABCA family

Target Tissue Specificity

[Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.

Target Synonyms

ABC2; Abca2; ABCA2_HUMAN; ATP binding cassette 2; ATP binding cassette sub family A member 2; ATP binding cassette transporter 2; ATP binding cassette; sub family A (ABC1); member 2; ATP binding cassette; sub family A; member 2; ATP binding cassette; sub family B (MDR/TAP); member 2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2

Target Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.