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The antibody against ACER3 was raised in rabbit using the Synthesized peptide derived from internal of Human PHCA. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against ACER3 was raised in rabbit using the Synthesized peptide derived from internal of Human PHCA. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC, IF.
$297.00
Western blot analysis of extracts from COLO cells, using PHCA antibody.
Immunohistochemistry analysis of paraffin-embedded human placenta tissue using PHCA antibody.2
Immunofluorescence analysis of MCF-7 cells, using PHCA antibody.3
| Cat.No | ADC-41499A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ACER3 |
| Target Synonyms | ACER3; APHC; PHCA; Alkaline ceramidase 3; AlkCDase 3; Alkaline CDase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; aPHC | Form | Liquid |
| Species Reactivity | Human, Mouse | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human PHCA. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NUN7 |
Uniprot Id
Q9NUN7
Target Species
Human
Target Name
ACER3
Target Full Name
Alkaline ceramidase 3
Target Function
Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Target Protein Families
Alkaline ceramidase family
Target Tissue Specificity
Ubiquitously expressed. Highly expressed in placenta. Expressed in erythrocytes.
Target Synonyms
ACER3; APHC; PHCA; Alkaline ceramidase 3; AlkCDase 3; Alkaline CDase 3; Alkaline dihydroceramidase SB89; Alkaline phytoceramidase; aPHC
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