Rabbit anti-Human Acetyl-alpha Tubulin -K40 Monoclonal Antibody

Uniprot Id

Q71U36

Target Species

Human

Target Name

TUBA1A

Target Full Name

Tubulin alpha-1A chain

Target Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Target Involvement

Lissencephaly 3 (LIS3)

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

Tubulin family

Target Tissue Specificity

Expressed at a high level in fetal brain.

Target Synonyms

Alpha tubulin 3; Alpha-tubulin 3; B alpha 1; FLJ25113; LIS3; TBA1A_HUMAN; TUBA1A; TUBA3; Tubulin alpha 1a; Tubulin alpha 1A chain; Tubulin alpha 3; Tubulin alpha 3 chain; Tubulin alpha brain specific; Tubulin alpha-1A chain; Tubulin alpha-3 chain; Tubulin B alpha 1; Tubulin B-alpha-1

Target Background

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.