Rabbit anti-Human ACLY Monoclonal Antibody

The antibody against ACLY was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 752-1101 of human ACLY (NP_001087.2) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-13508A

Number

Cat.No	ADA-13508A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	ACLY
Target Synonyms	ACL; ATPCL; CLATP; ACLY	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	C6, HeLa, NIH/3T3, HepG2, Mouse lung, Mouse testis	Application	ELISA, WB, IHC-P

Cat.No

ADA-13508A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

ACLY

Target Synonyms

ACL; ATPCL; CLATP; ACLY

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

C6, HeLa, NIH/3T3, HepG2, Mouse lung, Mouse testis

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 752-1101 of human ACLY (NP_001087.2).	Target Species	Human
Uniprot ID	P53396	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 752-1101 of human ACLY (NP_001087.2).

Target Species

Human

Uniprot ID

P53396

Immunogen Sequence

Background Information

Uniprot Id

P53396
Target Species

Human
Target Name

ACLY
Target Full Name

ATP-citrate synthase
Target Function

Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

Succinate/malate CoA ligase beta subunit family; Succinate/malate CoA ligase alpha subunit family
Target Research Area

Metabolism
Target Synonyms

ACL; Acly; ACLY_HUMAN; ATP citrate (pro-S) lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; ATPcitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773
Target Background

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Rabbit anti-Human ACLY Monoclonal Antibody

Specifications

Immunogen Information

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