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The antibody against Aconitase 2 (ACO2) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 501-780 of human Aconitase 2 (Aconitase 2 (ACO2)) (NP_001089.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against Aconitase 2 (ACO2) was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 501-780 of human Aconitase 2 (Aconitase 2 (ACO2)) (NP_001089.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-11240A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Aconitase 2 (ACO2) |
| Target Synonyms | ICRD; OCA8; OPA9; ACONM; HEL-S-284; Aconitase 2 (ACO2) | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Jurkat, Rat kidney | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 501-780 of human Aconitase 2 (Aconitase 2 (ACO2)) (NP_001089.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q99798 | Immunogen Sequence |
Uniprot Id
Q99798
Target Species
Human
Target Name
ACO2
Target Full Name
Aconitate hydratase, mitochondrial
Target Function
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Target Involvement
Infantile cerebellar-retinal degeneration (ICRD); Optic atrophy 9 (OPA9)
Target Subcellular Location
Mitochondrion.
Target Protein Families
Aconitase/IPM isomerase family
Target Research Area
Metabolism
Target Synonyms
ACO 2; ACO2; ACON_HUMAN; aconitase 2; Aconitase 2 mitochondrial; Aconitase; Aconitase2; Aconitate hydratase; Aconitate hydratase mitochondrial; ACONM; Citrate hydro lyase; Citrate hydro-lyase; ICRD; mitochondrial
Target Background
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.
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