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The antibody against ACSF3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 370-576 of human ACSF3 (NP_777577.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against ACSF3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 370-576 of human ACSF3 (NP_777577.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-08304A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ACSF3 |
| Target Synonyms | ACSF3; acyl-CoA synthetase family member 3 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat, Mouse liver | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 370-576 of human ACSF3 (NP_777577.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q4G176 | Immunogen Sequence |
Uniprot Id
Q4G176
Target Species
Human
Target Name
ACSF3
Target Full Name
Malonate--CoA ligase ACSF3, mitochondrial
Target Function
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Target Involvement
Combined malonic and methylmalonic aciduria (CMAMMA)
Target Subcellular Location
Mitochondrion.
Target Protein Families
ATP-dependent AMP-binding enzyme family
Target Synonyms
ACSF3; PSEC0197Malonate--CoA ligase ACSF3; mitochondrial; EC 6.2.1.n3; Acyl-CoA synthetase family member 3
Target Background
This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene.
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