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The antibody against ADAM12 was raised in rabbit using the Recombinant Human Disintegrin and metalloproteinase domain-containing protein 12 protein (730-909AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against ADAM12 was raised in rabbit using the Recombinant Human Disintegrin and metalloproteinase domain-containing protein 12 protein (730-909AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human placenta tissue using ADAM12 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using ADAM12 Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using ADAM12 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-14860A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADAM12 |
| Target Synonyms | ADAM12; MLTN; UNQ346/PRO545; Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; Meltrin-alpha | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 12 protein (730-909AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43184 |
Uniprot Id
O43184
Target Species
Human
Target Name
ADAM12
Target Full Name
Disintegrin and metalloproteinase domain-containing protein 12
Target Function
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
Target Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.
Target Tissue Specificity
Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancre
Target Synonyms
ADAM12; MLTN; UNQ346/PRO545; Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; Meltrin-alpha
Target Background
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.
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