Rabbit anti-Human ADAM19 Polyclonal Antibody

Uniprot Id

Q9H013

Target Species

Human

Target Name

ADAM19

Target Full Name

Disintegrin and metalloproteinase domain-containing protein 19

Target Function

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed in many normal organ tissues and several cancer cell lines.

Target Synonyms

ADAM19; MLTNB; FKSG34Disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; EC 3.4.24.-; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM

Target Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease.