Rabbit anti-Human ADAM28 Polyclonal Antibody

Uniprot Id

Q9UKQ2

Target Species

Human

Target Name

ADAM28

Target Full Name

Disintegrin and metalloproteinase domain-containing protein 28

Target Function

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

Target Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Target Tissue Specificity

Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed pref

Target Synonyms

ADAM28; ADAM23; MDCLDisintegrin and metalloproteinase domain-containing protein 28; ADAM 28; EC 3.4.24.-; Epididymal metalloproteinase-like; disintegrin-like; and cysteine-rich protein II; eMDC II; Metalloproteinase-like; disintegrin-like; and cysteine-rich protein L; MDC-L

Target Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants.