Rabbit anti-Human ADCY6/ADCY5 Polyclonal Antibody

Uniprot Id

O43306

Target Species

Human

Target Name

ADCY6

Target Full Name

Adenylate cyclase type 6

Target Function

Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.

Target Involvement

Lethal congenital contracture syndrome 8 (LCCS8)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cell projection, stereocilium.

Target Protein Families

Adenylyl cyclase class-4/guanylyl cyclase family

Target Tissue Specificity

Detected in peripheral blood mononuclear leukocytes (at protein level). Detected in thyroid.

Target Synonyms

AC6; ACVI; ADCY 6; Adcy6; ADCY6_HUMAN; ADCYB; Adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate lyase 6; ATP pyrophosphate-lyase 6; Ca(2+) inhibitable adenylyl cyclase; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075; EC 4.6.1.1; KIAA0422