Rabbit anti-Human ADGRG1 Polyclonal Antibody

Uniprot Id

Q9Y653

Target Species

Human

Target Name

ADGRG1

Target Full Name

Adhesion G-protein coupled receptor G1

Target Function

Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche. Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA. Plays an essential role in testis development.; Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA.

Target Involvement

Polymicrogyria, bilateral frontoparietal (BFPP); Polymicrogyria, bilateral perisylvian, autosomal recessive (BPPR)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.; [ADGRG1 N-terminal fragment]: Secreted.; [ADGRG1 C-terminal fragment]: Membrane raft.

Target Protein Families

G-protein coupled receptor 2 family, LN-TM7 subfamily

Target Tissue Specificity

Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells.