Rabbit anti-Human Adiponectin Monoclonal Antibody

Uniprot Id

Q15848

Target Species

Human

Target Name

ADIPOQ

Target Full Name

Adiponectin

Target Function

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Target Involvement

Adiponectin deficiency (ADPND); Diabetes mellitus, non-insulin-dependent (NIDDM)

Target Subcellular Location

Secreted.

Target Tissue Specificity

Synthesized exclusively by adipocytes and secreted into plasma.

Target Synonyms

ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1; Adiponectin

Target Background

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.