Rabbit anti-Human AEBP1 Polyclonal Antibody

Uniprot Id

Q8IUX7

Target Species

Human

Target Name

AEBP1

Target Full Name

Adipocyte enhancer-binding protein 1

Target Function

As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.; May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Target Subcellular Location

[Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm. Nucleus.

Target Protein Families

Peptidase M14 family

Target Tissue Specificity

Expressed in osteoblast and visceral fat.

Target Synonyms

AEBP1; ACLP; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein

Target Background

This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma.