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The antibody against AEN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AEN (NP_073604.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against AEN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AEN (NP_073604.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05224A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AEN |
| Target Synonyms | ISG20L1; pp12744; AEN | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AEN (NP_073604.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WTP8 | Immunogen Sequence |
Uniprot Id
Q8WTP8
Target Species
Human
Target Name
AEN
Target Full Name
Apoptosis-enhancing nuclease
Target Function
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Target Subcellular Location
Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
Target Research Area
Cell Biology
Target Synonyms
Aen; AEN_HUMAN; apoptosis enhancing nuclease; Apoptosis-enhancing nuclease; Interferon stimulated exonuclease gene 20kDa like 1; Interferon stimulated exonuclease gene 20kDa like 1; isoform CRA_a; Interferon-stimulated 20 kDa exonuclease-like 1; ISG20L1; pp12744
Target Background
Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm.
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