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The antibody against AEN was raised in rabbit using the Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against AEN was raised in rabbit using the Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
| Cat.No | ADC-40430A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AEN |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Apoptosis-enhancing nuclease protein (117-325AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WTP8 |
Uniprot Id
Q8WTP8
Target Species
Human
Target Name
AEN
Target Full Name
Apoptosis-enhancing nuclease
Target Function
Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
Target Subcellular Location
Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
Target Research Area
Cell Biology
Target Synonyms
Aen; AEN_HUMAN; apoptosis enhancing nuclease; Apoptosis-enhancing nuclease; Interferon stimulated exonuclease gene 20kDa like 1; Interferon stimulated exonuclease gene 20kDa like 1; isoform CRA_a; Interferon-stimulated 20 kDa exonuclease-like 1; ISG20L1; pp12744
Target Background
Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm.
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