Rabbit anti-Human AGAP2 Polyclonal Antibody

Uniprot Id

Q99490

Target Species

Human

Target Name

AGAP2

Target Full Name

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Target Function

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Target Subcellular Location

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm.

Target Protein Families

Centaurin gamma-like family

Target Tissue Specificity

Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.

Target Synonyms

AGAP-2; Agap2; Agap2 ArfGAP with GTPase domain; ankyrin repeat and PH domain 2; AGAP2_HUMAN; ANK repeat and PH domains 2; Arf GAP with GTP binding protein like; Arf GAP with GTP-binding protein-like; ANK repeat and PH domains 2; Arf GAP with GTP-binding protein-like; ankyrin repeat and pleckstrin homology domains 2; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2; ArfGAP with GTPase domain; ankyrin repeat and PH domain 2; Centaurin gamma 1; centaurin gamma1; Centaurin-gamma-1; Centg1; cnt g1; Cnt-g1; Cnt2; FLJ16430; GGAP2; GTP binding and GTPase activating protein 2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; KIAA0167; mKIAA0167; Nuclear GTPase PIKE; Phosphatidylinositol 3-kinase enhancer; Phosphoinositide 3 kinase enhancer ; PI3K ENHANCER; PIKE

Target Background

The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.