Rabbit anti-Human AGO1 Polyclonal Antibody

Uniprot Id

Q9UL18

Target Species

Human

Target Name

AGO1

Target Full Name

Protein argonaute-1

Target Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).

Target Subcellular Location

Cytoplasm, P-body.

Target Protein Families

Argonaute family, Ago subfamily

Target Synonyms

AGO1; AGO1_HUMAN; Argonaute 1; Argonaute 1 RISC catalytic component; Argonaute1; eIF 2C 1; eIF-2C 1; eIF2C 1; EIF2C; Eif2c1; Eukaryotic translation initiation factor 2C 1; GERP95; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo1; Protein argonaute 1; Protein argonaute-1; Putative RNA binding protein Q99; Putative RNA-binding protein Q99; Q99

Target Background

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.