Rabbit anti-Human AGRP Polyclonal Antibody

The antibody against AGRP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-01812A

Number

Cat.No	ADA-01812A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	AGRP
Target Synonyms	ART; AGRT; ASIP2; AGRP	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse skeletal muscle	Application	ELISA, WB, IHC-P

Cat.No

ADA-01812A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

AGRP

Target Synonyms

ART; AGRT; ASIP2; AGRP

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse skeletal muscle

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1).	Target Species	Human
Immunogen Sequence	AQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT	Uniprot ID	O00253

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1).

Target Species

Human

Immunogen Sequence

AQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT

Uniprot ID

O00253

Background Information

Uniprot Id

O00253
Target Species

Human
Target Name

AGRP
Target Full Name

Agouti-related protein
Target Function

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Target Involvement

Obesity (OBESITY)
Target Subcellular Location

Secreted. Golgi apparatus lumen.
Target Tissue Specificity

Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Target Research Area

Cardiovascular
Target Synonyms

Agouti related neuropeptide; Agouti Related Protein Homolog; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2
Target Background

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.

Rabbit anti-Human AGRP Polyclonal Antibody

Specifications

Immunogen Information

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